Npgrj_NCHEMBIO_128 26..28
نویسندگان
چکیده
Fluorination has gained an increasingly important role in drug discovery and development. Here we describe a versatile strategy that combines cytochrome P450–catalyzed oxygenation with deoxofluorination to achieve monoand polyfluorination of nonreactive sites in a variety of organic scaffolds. This procedure was applied for the rapid identification of fluorinated drug derivatives with enhanced membrane permeability.
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Etiological Aspects of Esophageal Atresia
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21 22 23 24 25 26 27 28 29 Article history: Received 28 January 2010 Received in revised form 26 August 2011 Accepted 30 August 2011 Available online xxxx
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